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- Event
- Posted 1 hour ago
Continuing Education at McLean Hospital
in Boston, United States -
- Event
- Posted 5 hours ago
Cell Stress and Biophysical Oncology Ph.D. Track
in Roswell, United States -
- Conference
- Posted 1 week ago
Deuel Conference
Between 3 Mar and 6 Mar in Coronado, United States -
- Conference
- Posted 2 months ago
Ca2+ Signaling: regulatory mechanisms to impact on health and diseases
Between 31 Jan and 1 Feb in Faridabad, India -
- Event
- Posted 2 months ago
RNAscope® - The RNA Revolution 2019 Lunch Seminar | In Situ Hybridization, RNA-ISH | ACDBio
in Newark, United States -
- Conference
- Posted 6 months ago
CCBIO's 9th Annual Symposium (2021)
Between 19 May and 20 May in Bergen, Norway -
- Conference
- Posted 6 months ago
4th World Congress on Cell Science and Molecular Biology (Cell Science-2020)
Between 11 May and 12 May in India -
- Conference
- Posted 7 months ago
2nd International Conference on PharmScience Research & Development
Between 24 Feb and 26 Feb in Los Angeles, United States -
- Conference
- Posted 7 months ago
2nd Head and Neck Conference: The Multidisciplinary Approach
Between 5 Dec and 6 Dec in Abu Dhabi, United Arab Emirates -
- Event
- Posted 7 months ago
Endoscopic Spine Surgery
Between 5 Dec and 6 Dec in Bordeaux, France -
- Study Advice, Career Advice
- Posted 10 months ago
4 Ideas to Promote Your Research
When you have important research to share, speaking at a conference is one of the best ways to network, create connections, and make your voice heard—but with so many people competing for attention, sometimes it can feel more like a drop in a bucket. In times like this, you need a secret weapon—something that makes your presentation stand out and ensures that audience members will remember it enough to take action. Check out our conference listings
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- Blog Post
- Posted 1 year ago
World Conference on Human Rights 1993
When thinking about conferences, we most often discuss academic conferences. However, throughout the twentieth century, the conference was an important meeting format for politicians and diplomats as well as academics. Some of the most important historical events of the century involved conference meetings which had a huge impact on national and international policy. One such key conference was the World Conference on Human Rights in 1993, which was the first human rights conference since the end of the Cold War and which was instrumental in specifying universal human rights.
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- Blog Post
- Posted 11 months ago
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1 micromolar). Cluster analysis identified potent and previously unreported scaffold families as well as other series previously associated with chemoprophylaxis.
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- Blog Post
- Posted 11 months ago
A valley valve and electron beam splitter
Developing alternative paradigms of electronics beyond silicon technology requires the exploration of fundamentally new physical mechanisms, such as the valley-specific phenomena in hexagonal two-dimensional materials. We realize ballistic valley Hall kink states in bilayer graphene and demonstrate gate-controlled current transmission in a four-kink router device. The operations of a waveguide, a valve, and a tunable electron beam splitter are demonstrated. The valley valve exploits the valley-momentum locking of the kink states and reaches an on/off ratio of 8 at zero magnetic field.
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- Blog Post
- Posted 11 months ago
A mechanistic classification of clinical phenotypes in neuroblastoma
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse.
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- Blog Post
- Posted 11 months ago
Temperature-dependent hypoxia explains biogeography and severity of end-Permian marine mass extinction
Rapid climate change at the end of the Permian Period (~252 million years ago) is the hypothesized trigger for the largest mass extinction in Earth’s history. We present model simulations of the Permian/Triassic climate transition that reproduce the ocean warming and oxygen (O2) loss indicated by the geologic record. The effect of these changes on animal survival is evaluated using the Metabolic Index (), a measure of scope for aerobic activity governed by organismal traits sampled in diverse modern species.
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- Blog Post
- Posted 11 months ago
Building two-dimensional materials one row at a time: Avoiding the nucleation barrier
Assembly of two-dimensional (2D) molecular arrays on surfaces produces a wide range of architectural motifs exhibiting unique properties, but little attention has been given to the mechanism by which they nucleate. Using peptides selected for their binding affinity to molybdenum disulfide, we investigated nucleation of 2D arrays by molecularly resolved in situ atomic force microscopy and compared our results to molecular dynamics simulations.
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- Blog Post
- Posted 11 months ago
Salmonella persisters undermine host immune defenses during antibiotic treatment
Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of Salmonella species by macrophages, nongrowing persisters also occur, but their physiological state is poorly understood. In this work, we show that Salmonella persisters arising during macrophage infection maintain a metabolically active state. Persisters reprogram macrophages by means of effectors secreted by the Salmonella pathogenicity island 2 type 3 secretion system.
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- Blog Post
- Posted 11 months ago
A DNA methylation reader complex that enhances gene transcription
DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream factors remain largely unknown. By using comparative interactomics, we isolated proteins in Arabidopsis thaliana that associate with methylated DNA. Two SU(VAR)3-9 homologs, the transcriptional antisilencing factor SUVH1, and SUVH3, were among the methyl reader candidates.
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- Blog Post
- Posted 11 months ago
Viscous control of cellular respiration by membrane lipid composition
Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids.
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- Blog Post
- Posted 11 months ago
Room-temperature cycling of metal fluoride electrodes: Liquid electrolytes for high-energy fluoride ion cells
Fluoride ion batteries are potential "next-generation" electrochemical storage devices that offer high energy density. At present, such batteries are limited to operation at high temperatures because suitable fluoride ion–conducting electrolytes are known only in the solid state. We report a liquid fluoride ion–conducting electrolyte with high ionic conductivity, wide operating voltage, and robust chemical stability based on dry tetraalkylammonium fluoride salts in ether solvents.
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- Blog Post
- Posted 11 months ago
LZTR1 is a regulator of RAS ubiquitination and signaling
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (LZTR1) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the Drosophila LZTR1 ortholog CG3711 resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms.
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- Blog Post
- Posted 11 months ago
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination
The leucine zipper–like transcriptional regulator 1 (LZTR1) protein, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, is implicated in human disease, yet its mechanism of action remains unknown. We found that Lztr1 haploinsufficiency in mice recapitulates Noonan syndrome phenotypes, whereas LZTR1 loss in Schwann cells drives dedifferentiation and proliferation. By trapping LZTR1 complexes from intact mammalian cells, we identified the guanosine triphosphatase RAS as a substrate for the LZTR1-CUL3 complex.
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- Blog Post
- Posted 11 months ago
Photonic crystals for nano-light in moire graphene superlattices
Graphene is an atomically thin plasmonic medium that supports highly confined plasmon polaritons, or nano-light, with very low loss. Electronic properties of graphene can be drastically altered when it is laid upon another graphene layer, resulting in a moiré superlattice. The relative twist angle between the two layers is a key tuning parameter of the interlayer coupling in thus-obtained twisted bilayer graphene (TBG). We studied the propagation of plasmon polaritons in TBG by infrared nano-imaging.
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- Blog Post
- Posted 11 months ago
A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play
The game of chess is the longest-studied domain in the history of artificial intelligence. The strongest programs are based on a combination of sophisticated search techniques, domain-specific adaptations, and handcrafted evaluation functions that have been refined by human experts over several decades. By contrast, the AlphaGo Zero program recently achieved superhuman performance in the game of Go by reinforcement learning from self-play. In this paper, we generalize this approach into a single AlphaZero algorithm that can achieve superhuman performance in many challenging games.